Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures

Genetic instability can result from increases in DNA damage and/or alterations repair proteins and contribute to disease development. Both exogenous endogenous sources of structure (e.g., non-B DNA) impact genome stability. Multiple mechanisms exist counteract damage. One key protein complex is ERCC1-XPF, a structure-specific endonuclease that participates variety processes. ERCC1-XPF involved nucleotide excision (NER), interstrand crosslinks (ICLs), double-strand break (DSB) via homologous recombination. In addition, contributes the processing various alternative (i.e., non-B) structures. This review will focus on structures by ERCC1-XPF.